glp-1 for alcohol use disorder medications get at the heart of addiction: study – WashU Medicine GLP-1 Therapeutics and Their Emerging

One patient achieved 33 percent total body weight loss over 115 weeks, but 91.2 percent of that weight loss came from fat, with only 8.7 percent from lean tissue

They also had improvements in overall brain function

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Although without total consensus, six components have been proposed to constitute the metabolic syndrome[300]: Abdominal obesity (or increased waist circumference), atherogenic dyslipidemia (hypertriglyceridemia and low high-density lipoprotein cholesterol concentrations), raised blood pressure, insulin resistance with glucose intolerance, pro-inflammatory state (elevated C-reactive protein) and a pro-thrombotic state (with increased plasminogen activator inhibitor-1 and fibrinogen)

A 2025 meta-analysis found that semaglutide increased the relative risk of cholelithiasis (gallstones) by 1.92 , liraglutide by 1.75 , and tirzepatide by 1.36