Implications of trimethylamine N-oxide (TMAO) and betaine in human health: beyond being Osmoprotective compounds
Other noteworthy phase 3 trial readouts in 2025 include: Novo Nordisks evoke/evoke+ , investigating oral semaglutide in patients with early Alzheimers disease, potentially expanding the utility of GLP-1s beyond cardiometabolic indications
Dietary modifications that may support metabolic health include: Including a source of protein at each meal, as protein can stimulate GLP-1 release Including dietary fibre , particularly soluble fibre from vegetables, legumes, oats, and wholegrains, which may promote GLP-1 secretion through fermentation by gut bacteria Eating regular, balanced meals that align with the NHS Eatwell Guide recommendations Limiting ultra-processed foods high in refined carbohydrates and unhealthy fats Considering fermented foods such as yoghurt, kefir, and sauerkraut, which may benefit overall gut health, though direct effects on GLP-1 require further research Lifestyle factors that support metabolic health include: Regular physical activity , with both aerobic exercise and resistance training showing benefits for glucose metabolism
Short-chain fatty acid receptor and its contribution to glucagon-like peptide-1 release
But there is a more accurate way to learn about an individuals overall level of health and fitness as well as where improvements can be madenamely, by assessing body composition
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