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Without adequate B12, homocysteine levels rise, and elevated homocysteine is neurotoxic, potentially causing direct damage to nerve cells and blood vessels that supply nerves

BPC-157 works through vascularization and growth factor modulation

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The 2017 Neelakantan paper in Biochemistry characterised a fluorescent assay for direct real-time monitoring of NNMT enzymatic activity, providing the analytical foundation for inhibitor screening including 5-Amino-1MQ (PMID 28121423)

Transforming growth factor-beta 1 (TGF-beta1) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated apoptosis