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Recycling of BH 4 requires dihydrofolate reductase (DHFR), and if DHFR is inhibited, then BH 4 cooperates with GPX4 to induce ferroptosis [48]

5FU-resistant HCT116 cells were generated by chronic exposure to 5FU

doi: 10.1016/j.bone.2019.115079 101 TorekovSSHarslfTRejnmarkLEikenPJensenJBHermanAPet al

A L-Carnitina se relaciona ao metabolismo lipdico porque atua como carreadora de cidos graxos de cadeia longa at o interior das mitocndrias, a fim de que sejam oxidados para servirem como fonte energtica muscular