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Including covariates, such as alcohol use, may be particularly important as a recent mega-analysis of 2140 individuals with substance use disorders found reduced volume in several regions, but follow-up analyses clarified these effects were primarily related to alcohol dependence with no effects when the analyses were restricted to individuals who currently smoke cigarettes ( n = 602) [15]

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The Yenidje Orientals that gave the original Sobranie its distinctive character are essentially extinct in commercial quantities