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Tesofensine Side Effects Because tesofensine acts as a central nervous system stimulant, its side effects tend to be stimulant-related: Dry mouth reported by 3040% of participants in clinical trials Insomnia difficulty falling or staying asleep, particularly if taken later in the day Increased heart rate mean increases of 58 beats per minute were observed in trials

The main difference is that Wegovy injections can cause injection site reactions (such as irritation), while the pills do not

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An internal Merck filing notes that, post-2026, Januvia/Janumet sales are expected to plunge as generics capture market share ( [13] )

PubMed Central , Vigil, Pilar, et al