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1, 5, 6, 7 Each successive regimen achieves a less durable response, suggesting emergence of a resistant phenotype and therefore MM remains largely incurable

Frontiers in Bioengineering and Biotechnology, 7 , Article 205

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Pegaptanib, a VEGF antagonist with a three-dimensionally structured aptamer, was initially used to inhibit pathological neovascularization and reverse disease progression but was later removed from the market

Furthermore, there may also be a contribution made by reactivation of latent viruses