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Exercise-induced activation of AMPK and LKB1 has been extensively shown in both humans and animals

These conservative measures should be implemented for 12 weeks before escalating to pharmacologic interventions, unless symptoms are severe or significantly impact quality of life

2.3.4 AMPK Adenosine monophosphate-regulated protein kinase (AMPK), a receptor of cellular energy status expressed in cardiomyocytes, is an essential part of CF (Harada et al., 2015)

NICE-recommended approaches to obesity management emphasise a multidisciplinary framework that includes dietary intervention, physical activity, behavioural support, and where appropriate pharmacotherapy or bariatric surgery

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