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Increased Risk of Hypoglycemia (Low Blood Sugar): While both drugs individually have a lower risk of hypoglycemia compared to some other diabetes medications, combining them, especially if not carefully managed or if lifestyle factors are not optimized, can slightly increase this risk

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Risks and Unknowns Remaining research gaps include: Long-term systemic administration data Optimal dosing strategies outside dermatology Interaction with copper metabolism disorders Comparative efficacy versus standard wound treatments Most evidence supports local, tissue specific effects rather than systemic transformation

doi: 10.1159/000489241

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