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BiJMinZYuanHJiangZMaoRZhuTet alPI3K inhibitor treatment ameliorates the glucocorticoid insensitivity of PBMCs in severe asthma

This was the highest average increase observed across any dose group at any time point

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Loss of redox flexibility compromises protein thiol regulation, redox-sensitive signaling pathways, and endothelial homeostasis, positioning glutathione insufficiency as a primary upstream disturbance rather than a downstream consequence of disease (1-3)