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Thyroid C-Cell Tumors: In mice and rats, tirzepatide (the active ingredient in Zepbound and Mounjaro) caused an increase in thyroid C-cell tumors, including medullary thyroid carcinoma (MTC)

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The findings are intriguing and encouraging, said the studys senior author, Paul Harrison, Theme Leader in the NIHR Oxford Health Biomedical Research Centre, and a Group Leader in the Oxford Wellcome Centre for Integrative Neuroimaging

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SURMOUNT-2 in adults with type 2 diabetes showed average weight loss of 12.8% on the 10mg dose and 14.7% (approximately 33 lbs) on the 15mg dose, versus 3.2% for placebo