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Hepatic G6PD enzymatic activity is diminished in G6PD-deficient individuals (93), can be altered in non-deficient individuals by exogenous factors, such as insulin and high fat diets (94, 95), and can be upregulated to meet increased demand in states of physiologic stress

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10.1021/acsnano.0c05499 64 WangL.YuY.WeiD.ZhangL.ZhangX.ZhangG.et al (2021)

All evidence comes from rodent models, cell cultures, or ex vivo tissue samples