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Protocol as for acetaminophen toxicity: 140 mg/kg IV initially: slow bolus not constant rate infusion (ammonia toxicity) then 70 mg/kg IV or PO x 3-6 (or more) treatments given at 8 to 12 hour intervals

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Meta-analyses of clinical trials indicate that KD leads to faster weight loss in the short term, with optimal results usually achieved within the first 36 months (71, 72)