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During development and progression of atherosclerosis, Nrf2 signaling modulates many physiological and pathophysiological processes, like regulation of lipid homeostasis, CD36 gene expression regulation, foam cell formation, macrophage polarization, immunity regulation (Th2 differentiation and inhibition of pro-inflammatory gene expression through NFB down-regulation), redox regulation and inflammation, improvement of endothelial dysfunction, as well as GSH synthesis and utilization (234245)

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Glutathione and immune function A foundational 2000 study revealed glutathiones importance in lymphocyte activitydemonstrating that even moderate shifts in intracellular glutathione greatly impact DNA synthesis and immune signaling pathways

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Increased levels of glutathione in the body improves immune function