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Principally, estrogen action and the gut microbiome in dermal health have been covered in detail recently by Lephart and Naftolin, 2022 (Dermatology and Therapy online, hardcopy in press)

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When examining the neurotrophic properties of GLP-1 and exenatide on cultured hippocampal neurons and in a rodent model of neurodegeneration, treatment with GLP-1 and exendin-4 was found to prevent and reverse excitotoxic neuronal damage, as measured by increased cholinergic marker activity [96]

In contrast, O 2 -is an efficient oxidant of metalloenzymes (10 4 M 1 s 1 ), presumably because anionic O 2 -forms a stable electrostatic complex with cationic iron cofactors ( 2 O 2

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