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Cancer Cell 21 , 297308 (2012)

It is composed of the tripeptide glycylLhistidylLlysine bound to a divalent copper ion, forming a highaffinity chelated structure that enables controlled copper handling within biological environments

A key pathological mechanism linking obesity to metabolic complications is insulin resistance (IR), a reduced biological response to insulin in target tissuesprimarily skeletal muscle, liver, and WAT [7]