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310 Similar effects are observed after transgenic deletion of Ccl2 specifically from astrocytes, which showed little effects early in EAE but demonstrated that astrocyte Ccl2 sustains disease symptoms and inflammation during chronic EAE, making it a therapeutic target

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All this evidence feeds into our conclusions: GLP-1s are clinically valuable but financially burdensome at current scale, leading payers to implement controls and selective coverage, which in turn shapes patient experiences

Using a dose below the beginner range may be ineffective