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An essential and distinctive component of this fluid is the remarkably high concentration of citrate

(PubMed) Hagen TM, Vinarsky V, Wehr CM, Ames BN

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doi: 10.3389/fendo.2023.1271521 Received 02 August 2023 Accepted 17 November 2023 Published 30 November 2023 Volume 14 - 2023 Edited by Ashu Johri, Independent Researcher, New York, NY, United States Reviewed by Shubhadeep Roychoudhury, Assam University, India

While scientists have known for several decades that cholesterol and calcium salts play a major role in gallstone formation, it was not clear how the cholesterol and calcium salts adhered together, forming gallstones