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The most common skin manifestations include a pale, washed-out complexion from anemia, dryness and cracking (particularly at the corners of the mouth), hyperpigmented patches on the hands or face, and glossitis a swollen, smooth, unusually red tongue

Injecting B12 on top of an undiagnosed cause masks the underlying deficiency picture and can delay diagnosis of pernicious anaemia

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Animal models showed exercise-equivalent effects (mitochondrial biogenesis, fat oxidation, endurance gains) without physical activity

doi: 10.1073/pnas.2009620118 16 EppSMaherSAzizAAAMarconeSEganDHaapa-PaananenSet al