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It is to be understood that the bivalent spacer linkers may be combined in any chemically relevant way, either directly or via an intervening heteroatom to construct the releasable linkers described herein

In select cases, and only under the strict guidance and supervision of a qualified healthcare professional , a modified dosing frequency, such as splitting a weekly dose into smaller, more frequent injections, might be explored as a strategy to manage side effects and improve patient tolerability

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In previous studies by our group, the ATC system was applied for drug utilization research (Bindel and Seifert 2025a, 2025b, 2025c)