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Semaglutide is a GLP-1 receptor agonist, a class of medications that mimic a natural hormone released after eating

This persistent immune activation isn't just a symptom

These types of reactions often look like small red spots or a mild heat-like rash and usually subside as the body finds its new balance

True medication failure presents as loss of all subjective effects: appetite suppression gone, food noise returned, portion sizes increased, and characteristic medication sensations absent

veterans with Type 2 diabetes for three years, comparing those who stayed on GLP-1 medications continuously with those who stopped or took extended breaks