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Treatment of rats with roridin E caused minimal toxicity on the hepatic and renal tissue, however, co administration of linoleic acid with roridin E resulted in increase toxicity due to increased incorporation to the cell membrane or inhibit its biotransformation [159]

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185 YanJ.WangH.LiuY.ShaoC

The GSH content (%) was calculated from the intracellular GSH concentration (mg/L) divided by DCW

These characteristics, combined with its demonstrated bioactivity across diverse tissue types, suggest it may serve as a model compound for further pharmacological exploration