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Accessed 2026
Especially with persistent fatigue, tingling, nausea or vitamin B12 deficiency, it makes sense to look deeper
The copper component serves as an essential cofactor for lysyl oxidase and lysyl hydroxylase, enzymes critical for proper collagen cross-linking
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Beside low plasma levels of vitamin B12 in people with vitamin B12 deficiency, the plasma concentrations of methylmalonic acid (MMA) become elevated due to the impaired activity of the mitochondrial methylmalonyl-coenzyme A (CoA) mutase, that converts succinyl-CoA to methylmalonyl-CoA
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