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Grade 2 refers to a reduction in oral intake that does not result in significant weight loss, dehydration, or malnutrition, and Grade 3 represents nausea leading to inadequate oral caloric or fluid intake, where nutritional support such as tube feeding or total parenteral nutrition, or hospitalization, may be indicated

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In addition to vitamin D3, which promotes the absorption of calcium and phosphorus in the intestine, its active metabolite, osteotriol, can also directly participate in bone mineral metabolism without hepatic or renal hydroxylation (32)