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But heres the nuance most people miss: This is not CPAP independence Patients remained on PAP during trials Improvements are largely weight-driven So the correct framing is: OSA improvement = proven CPAP replacement = not proven Why this matters commercially OSA is: Diagnosable Specialist-managed Reimbursable That makes it far more valuable than pure obesity

Integration into clinical practice will rely on forthcoming phase III data, cost-effectiveness analyses, and evolving guidelines

Bioavailability is route-dependent and lower than injection or IV

That is a clinically significant reduction, comparable to what you would expect from a dedicated blood pressure medication

Representative intensity-response curves are provided in Supplementary Fig