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Phytochemicals such as, the Resveratrol (3,4,5-trihydroxy stilbene) and the Curcuminoids (with , -unsaturated carbonyl groups) are potential inducers of HO-1 expression through Nrf2/ antioxidant-responsive element (ARE) pathway 471,472

This is the recommended first route for individuals who hold any unused preparation

The process allows it to be rapidly distributed throughout the body

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Ferritinophagy, a ferritin degradation pathway, depends on NCOA4 (Lin et al., 2020), a selective cargo receptor for the autophagic turnover of ferritin by lysosomes (Mancias et al., 2014)