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A small case-controlled study comparing 52 DS cases to 52 control cases noted that average maternal serum homocysteine concentration was slightly higher in mothers giving birth to children with DS but this difference was not statistically significant (Mohanty et al 2012)

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The peptide also plays a role in improving sleep quality and restoring endocrine balance by improving melatonin production

Choline synthesis in the body depends both on having enough of the PEMT enzyme (genetics) as well as sufficient methyl groups (diet, genetics) along with methionine (amino acid, abundant in high protein foods)