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On the appetite side the two pathways are genuinely distinct and additive, which is the biological rationale for the combination and helps explain why CagriSema produced greater weight loss than either mechanism alone in the obesity program

[DOI] [PubMed] [Google Scholar] 115.Clapper M.L., Szarka C.E., Pfeiffer G.R., Graham T.A., Balshem A.M., Litwin S., Goosenberg E.B., Frucht H., Engstrom P.F

Dexamethasone treatment (100 nM) resulted in a 3-fold and 2.4-fold reduction in SSTR2A and SSTR2B mRNA levels, respectively