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Who Should Not Use Contrave Contrave is not recommended for patients who: Take chronic opioid medications Have a history of seizures Have uncontrolled anxiety or panic disorders Have uncontrolled hypertension Are pregnant or planning pregnancy These safety considerations help ensure that Contrave is used only in appropriate clinical contexts

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Additionally, hormonal changesincluding alterations in leptin, ghrelin, and thyroid hormonescan influence appetite and energy balance, making continued weight loss more challenging

Although the committees recommendations often carry significant weight in the FDAs decision-making, they are advisory rather than binding