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47,290 In neutrophils, Toll/interleukin-1 receptor domain-containing protein C (TcpC) is an E3 ubiquitin ligase that targets peptidyl arginine deiminase 4 (PAD4), inhibiting the formation of NETs by enhancing the ubiquitination-mediated degradation of PAD4

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Our results demonstrate that the loss of Stard7 in IECs impairs mRNA levels of pro-inflammatory cytokines in the inflammation-driven model of intestinal cancer but enhances their mRNA levels in Apc +/min mice