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Figura 1: ciclo vitale dello Schistosoma Figura 2: una coppia di Schistosomi (la femmina e' ospitata nel canale ginecoforo del maschio) vista col microscopio elettronico a scansione Figura 3: la larva cercaria We studied the following enzymes/proteins form Schistosoma mansoni (and haematobium) that have potential interest as vaccine antigens or drug targets: - Glutathione S-transferase (GST) - Cyclophilin (Cyp) - Fatty Acid Binding Protein (FABP) - Thioredoxin Glutathione Reductase (TGR) - Thioredoxin (Trx) - Glutathione peroxidase (Gpx) - Thioredoxin peroxidase (peroxiredoxin, Prx) Thiol reductases in Schistosoma parasites - In all organisms thiols play a crucial metabolic role in the detoxification of oxidizing substances (thioredoxin peroxidase, glutathione peroxidase, glutathione S-transferase) and in the bisynthesis of DNA (ribonucleotide reductase)

10.1016/j.arr.2023.102063 516 YangL.WangD.WangX

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This includes comprehensive pre-clinical and clinical trials, coupled with toxicological studies, to solidify its position in the pharmaceutical and nutraceutical industries

The outlook reflects the company's ability to leverage a favorable rate environment, technological efficiency and a diversified business model