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We and others have previously identified SW837 rectal cancer and HCT116 colon cancer cells as an in vitro model of inherently radioresistant, and radiosensitive CRC, respectively ( Metformin treatment (2.5 mM and 10 mM) significantly sensitised radiosensitive HCT116 cells to 1.8 Gy radiation, when compared to vehicle control ( Figure 1F ) (relative mean surviving fraction (SF) standard error of mean (SEM)

Bacterial cells were washed three times with PBS before infection

The ligand-binding domain and DNA-binding site regions are highly conserved among these receptors, whereas the amino-terminal domain region has more significant variability on its sequence and length (Higa and Fell, 2013)

The liver processes these substances in two distinct stages, known as Phase I and Phase II detoxification

By preventing NNMT from draining the nicotinamide pool, 5-amino-1mq helps maintain NAD+ at levels that support optimal energy production