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Because GHK-Cu copper peptide can be delivered intranasally, bypassing the restrictive blood-brain barrier, this route was selected as an efficient and non-invasive way to achieve central nervous system exposure

Any value equal to or greater than 25 mol/L was classified normal free carnitine

: up-regulate or increase

Major advantages of transethosomes are better-bypassing first-pass metabolism, non-invasive drug administration technique making it more patient-friendly, and increased skin permeability, allowing deeper drug penetration

Moreover, IHC staining showed that FA not only induced the expression of p53 but also promoted p53 abundance in nucleus