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In SUSTAIN 6 and PIONEER 6, both powered to demonstrate noninferiority (upper 95% confidence interval [CI] of the hazard ratio [HR] 7% and at high risk of CV events, defined as: i) aged 50 years with established CVD (previous CV, cerebrovascular, or peripheral vascular disease), chronic heart failure (HF) (New York Heart Association [NYHA] class II or III), or chronic kidney disease (CKD) stage 3

The newly approved oral GLP-1 orforglipron (Foundayo) is a distinct non-peptide small molecule with its own independent patent timeline.

July 1, 2025

The scale doesn't always tell the whole story, and success looks different for everyone

These reactions are generally mild, self-limiting, and resolve within a few days without intervention