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These metrics, particularly the confidence estimate and scalability index, are utilized by the system, or can be used by the chemist, to rank and prioritize competing retrosynthetic pathways

If GI symptoms are still significant, the documented approach is to hold the current dose longer rather than escalate on schedule

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Speculatively, this could be due to different physiologic responds to food during day and evening, however the results could be biased by the fact that the hormonal response might be different in a fasted state than in a well fed state and furthermore our blood sample frequency are not high enough to surely capture the peak or nadir values after a meal

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