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Moreover, the interplay between conserved signaling pathways, such as those implicated in aging (predominantly involving the PI3K-AKT route), and lesser known pathways, such as those mediated by biased G-protein coupled receptors and others even less known, may underpin the context-dependent actions characteristic of ILPs signaling

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The localization of these oxidized protein deposits appears non-coincident to those of A aggregation, suggesting a separate age-related pathway for oxidation of protein

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