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Semax is primarily studied as a nootropic peptide associated with cognitive enhancement, neuroprotection, and neurotrophic signaling, including brain-derived neurotrophic factor (BDNF)

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Segura attributed the growing deficit to two primary factors, beginning with declining enrollment linked to immigration changes

Nearly all studies originate from one research group, raising concerns about independent replication

The Rome diagnostic criteria frequently overlap with symptoms of other organic GI diseases, making differentiation challenging