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Phase 3: Maintenance (Weeks 912) Dose: 23 weekly Pulsed administration keeps the repair signal present without turning the protocol into constant stimulation

[3] [4] Absolute contraindications include prior idiosyncratic hypersensitivity to topiramate or any tablet excipient

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In the Phase 2 trial, participants showed reductions in liver fat content as measured by MRI-based proton density fat fraction (MRI-PDFF) assessments, with some individuals demonstrating marked reductions in hepatic steatosis