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Description

Associations were strongest for urate transporters, particularly SLC2A9 and ABCG2, accounting respectively for 2-3% and 1% of the variance in serum urate levels in Europeans and to a lesser degree, SLC22A12, SLC22A11 (which encodes OAT4, a transporter involved in renal urate reabsorption) (Figure 1-4-A), and SLC17A1 (which encodes NPT1, a transporter mediating renal urate secretion (Figure 1-4-B)

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Digested tissue was filtered through 70 m strainer to obtain a single cell suspension

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Patients with renal impairment must also be screened carefully

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Bean, C

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