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These NETs are intricate networks of chromatin fibers decorated with antimicrobial proteins (e.g., neutrophil elastase, cathepsin G, and histones that have a high affinity for DNA) released by neutrophils during a programmed cell death called NETosis (113, 114)

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In contrast, the hyphal form, mediated by the cAMP-dependent protein kinase-A (PKA) pathway, the mitogen-activated protein kinase [MAPK] cascade [75], and the calcium calmodulin-mediated signal transduction pathway, possesses the ability to invade the protective layers either by active penetration or by induced endocytosis [76]

doi: 10.1358/dnp.2004.17.7.863703 51 AmaraURittirschDFlierlMBrucknerUKlosAGebhardFet al

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