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Pharmacol Res 220:107927 Jun L, Tao YX, Geetha T, Babu JR (2024) Mitochondrial adaptation in skeletal muscle: impact of Obesity, caloric Restriction, and dietary compounds

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Regulatory Status: CagriSema (cagrilintide-semaglutide combination) NDA was submitted to the FDA in December 2025 for once-weekly treatment of overweight or obesity with weight-related comorbidities

As with any powerful therapy, there are questions we still need to answer: how these drugs behave over decades, how to protect lean mass at scale, how to dose safely in metabolically healthy individuals, how to separate genuine medical use from cosmetic hype, and how to ensure patients are not starved of protein or muscle