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A unified model of the pathophysiology of bipolar disorder

One milligram kept most of the 2.4 mg weight effect in a diabetes trial, and 0.5 mg has years of use behind it. Small real-world series also suggest that reduced-frequency dosing can hold a plateau

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Weight loss injections should only be used on prescription and in conjunction with medical advice, and particular consideration must be given around people at risk of eating disorders.

This matters because insulin resistance impairs hormone-sensitive lipase (HSL), the enzyme that liberates fatty acids from triglyceride stores in fat cells