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MOTS-c primarily works through metabolic pathways rather than direct hormonal manipulation

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Discovery and preclinical profile of saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

The manufacturer discontinued both formulations in 2008 for business reasons, and a 2013 Federal Register determination confirmed the withdrawal was not for reasons of safety or effectiveness