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If skin symptoms appeared or worsened following dose escalation, discussing with the prescribing provider whether to maintain the current dose longer before further titration, or whether a temporary dose reduction might be appropriate, could be considered

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Nonetheless, BMI was directly associated with higher risk of severe hospitalization, longer hospital stays and increased surgical intervention rates, mainly due to metabolic comorbidities (89)

McGovern A, Tippu Z, Hinton W, Munro N, Whyte M, de Lusignan S (2018) Comparison of medication adherence and persistence in type 2 diabetes: a systematic review and meta-analysis

Additionally, they found that mitochondrial dynamics abnormalities were present in the early stages of AD development