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And then when we look at the gut biome, is there a mast cell activation

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Furthermore, in a paraquat-induced fibrosis model, Xuebijing injection, a traditional Chinese medicine compound, corrected elevated levels of L-valine, glycine, and L-tryptophan, indicating its antifibrotic potential may be related to rebalancing amino acid metabolic disturbances [165]

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Secondly, sometimes the microbiota may not have antigens similar to the host structure, but it can induce co-stimulation and cytokine production through antigen presenting cells, leading to the activation of bystander T cells [72, 73]