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In the case of GLP-1, infusion of glucose into the duodenum at 2 kcal/min (where glucose is absorbed in the upper gut) elicits minimal GLP-1 secretion, while ileal infusion of glucose at the same rate induces substantial GLP-1 release (77)
General switching guidelines: Notice that even people on the maximum semaglutide dose (2.4 mg) typically start tirzepatide at 5 mg, not at a higher dose
The most successful patients I work with view these medications as one component of a comprehensive strategy, not a standalone solution
Next-generation, long-acting, and patient-friendly formulations are advanced drug versions designed to work over extended periods, reduce dosing frequency, and make treatment easier and more convenient for patients
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