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To overcome the short half-life and frequent subcutaneous administration of pramlintide, new amylin receptor agonists like cagrilintide have been developed

Reports submitted to the FDA's MedWatch system and documented in peptide safety reviews describe nausea, transient hypotension, lightheadedness, flushing, and mild headache following doses above the typical range 10

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These may include: Nausea and stomach upset Diarrhea Constipation Injection site redness or swelling Itching Headache Dizziness Blood clots Swelling In rare cases, some people may experience an allergic reaction to vitamin B12, which can cause symptoms such as hives, difficulty breathing, and swelling of the face, lips, tongue, or throat

Quality control issues present practical safety concerns beyond inherent peptide properties