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Human plasma samples were analyzed using both NMR spectroscopy and LCMS/MS for -HB and AcAc quantification, while acetone was measured by GCMS

Persistent fever and elevated inflammatory markers (CRP, troponin, etc.) have been seen in the affected patients

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In a randomized, double-blind, placebo-controlled trial, tesamorelin reduced liver fat and was associated with less fibrosis progression, and a targeted proteomic and transcriptomic analysis of that trial showed the drug lowered fibro-inflammatory mediators including VEGFA, TGF-1, and CSF1