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Unlike antioxidants that scavenge reactive oxygen species after formation, SS-31 selectively binds to cardiolipin, a phospholipid essential for mitochondrial inner membrane structure and electron transport chain function

395 In other words, ZIP4 upregulated the expression of ZEB1 in PC, which in turn induced a substantial downregulation of gemcitabine uptake protein ENT1 by integrin 31, ultimately limiting drug internalization through activation of the MAP kinase JNK

The effect on cognitive function has also been examined in 36 individuals with Type 2 diabetes mellitus and mild cognitive impairment assessed by the Mini-Mental State Examination (MMSE) score