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In terms of sustained antidepressant efficacy and downstream long-lasting synaptic plasticity, there is also a body of important evidence for the ketamine metabolite (2R,6R)-hydroxynorephedrine (2R,6R-HNK)

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Verdonk F, Petit AC, Abdel-Ahad P, Vinckier F, Jouvion G, de Maricourt P, et al

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